Senior Principal Scientist, Agentic Systems Development for Drug Discovery Job at Vertex Pharmaceuticals, Boston, MA

  • Vertex Pharmaceuticals
  • Boston, MA

Job Description

Vertex Pharmaceuticals seeks a Senior Principal Scientist to develop and deploy agentic AI systems for drug discovery. The role combines computational expertise with scientific leadership to create AI-enabled workflows that enhance small molecule and protein therapeutic discovery, requiring strong cheminformatics and software engineering capabilities.

Responsibilities

  • Translate scientific requirements into autonomous agentic AI solutions for drug discovery
  • Build, test, and deploy AI-enabled scientific workflows across small molecule and protein therapeutics
  • Design testing, evaluation, and validation strategies for agentic AI systems
  • Collaborate with computational scientists, engineers, and research teams on scalable AI solutions
  • Stay current with emerging agentic AI patterns and prototype new scientific capabilities

Requirements

  • Ph.D. in Computational Chemistry, Cheminformatics, or related scientific discipline
  • 8+ years experience in scientific software development applied to drug discovery
  • Expert knowledge of small molecule computational methods and cheminformatics
  • Hands-on experience developing, deploying, and managing AI-enabled scientific products
  • Strong Python skills and production-grade software development capabilities
  • Deep understanding of agentic AI systems, LLMs, and modern AI technologies
  • Experience translating scientific requirements into scalable computational solutions

Compensation: $168,000 - $252,000 base

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